EDUCATION
1992 - 1998
1986 - 1990 |
Ph.D. in Microbiology and Immunology
University of North Carolina at Chapel Hill Advisor: Thesis: Bachelor of Science in Zoology University of Maryland |
TOP 10 PUBLICATIONS
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA. Blood. 2006 Jun 15;107(12):4781-9. doi: 10.1182/blood-2005-12-4818. Epub 2006 Feb 7. PMID: 16467198; PMCID: PMC1895811.
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ. Nat Immunol. 2009 Jan;10(1):29-37. doi: 10.1038/ni.1679. Epub 2008 Nov 30. PMID: 19043418; PMCID: PMC2605166.
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA. J Immunol Methods. 2003 Oct 1;281(1-2):65-78. doi: 10.1016/s0022-1759(03)00265-5. PMID: 14580882.
HIV preferentially infects HIV-specific CD4+ T cells
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. Nature. 2002 May 2;417(6884):95-8. doi: 10.1038/417095a. PMID: 11986671.
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA; UPenn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ. Science. 2020 Sep 4;369(6508):eabc8511. doi: 10.1126/science.abc8511. Epub 2020 Jul 15. PMID: 32669297; PMCID: PMC7402624.
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. Blood. 2003 Apr 1;101(7):2711-20. doi: 10.1182/blood-2002-07-2103. Epub 2002 Nov 14. PMID: 12433688.
Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses: relationship to viral load in untreated HIV infection
Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, Koup RA, Picker LJ. J Virol. 2001 Dec;75(24):11983-91. doi: 10.1128/JVI.75.24.11983-11991.2001. PMID: 11711588; PMCID: PMC116093.
Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution
Douek DC, Vescio RA, Betts MR, Brenchley JM, Hill BJ, Zhang L, Berenson JR, Collins RH, Koup RA. Lancet. 2000 May 27;355(9218):1875-81. doi: 10.1016/S0140-6736(00)02293-5. PMID: 10866444.
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA. J Exp Med. 2007 Jun 11;204(6):1405-16. doi: 10.1084/jem.20062363. Epub 2007 May 29. PMID: 17535971; PMCID: PMC2118607.
Comprehensive mapping of immune perturbations associated with severe COVID-19
Kuri-Cervantes L, Pampena MB, Meng W, Rosenfeld AM, Ittner CAG, Weisman AR, Agyekum RS, Mathew D, Baxter AE, Vella LA, Kuthuru O, Apostolidis SA, Bershaw L, Dougherty J, Greenplate AR, Pattekar A, Kim J, Han N, Gouma S, Weirick ME, Arevalo CP, Bolton MJ, Goodwin EC, Anderson EM, Hensley SE, Jones TK, Mangalmurti NS, Luning Prak ET, Wherry EJ, Meyer NJ, Betts MR. Sci Immunol. 2020 Jul 15;5(49):eabd7114. doi: 10.1126/sciimmunol.abd7114. PMID: 32669287; PMCID: PMC7402634.
Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA. Blood. 2006 Jun 15;107(12):4781-9. doi: 10.1182/blood-2005-12-4818. Epub 2006 Feb 7. PMID: 16467198; PMCID: PMC1895811.
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ. Nat Immunol. 2009 Jan;10(1):29-37. doi: 10.1038/ni.1679. Epub 2008 Nov 30. PMID: 19043418; PMCID: PMC2605166.
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA. J Immunol Methods. 2003 Oct 1;281(1-2):65-78. doi: 10.1016/s0022-1759(03)00265-5. PMID: 14580882.
HIV preferentially infects HIV-specific CD4+ T cells
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. Nature. 2002 May 2;417(6884):95-8. doi: 10.1038/417095a. PMID: 11986671.
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA; UPenn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ. Science. 2020 Sep 4;369(6508):eabc8511. doi: 10.1126/science.abc8511. Epub 2020 Jul 15. PMID: 32669297; PMCID: PMC7402624.
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. Blood. 2003 Apr 1;101(7):2711-20. doi: 10.1182/blood-2002-07-2103. Epub 2002 Nov 14. PMID: 12433688.
Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses: relationship to viral load in untreated HIV infection
Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, Koup RA, Picker LJ. J Virol. 2001 Dec;75(24):11983-91. doi: 10.1128/JVI.75.24.11983-11991.2001. PMID: 11711588; PMCID: PMC116093.
Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution
Douek DC, Vescio RA, Betts MR, Brenchley JM, Hill BJ, Zhang L, Berenson JR, Collins RH, Koup RA. Lancet. 2000 May 27;355(9218):1875-81. doi: 10.1016/S0140-6736(00)02293-5. PMID: 10866444.
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA. J Exp Med. 2007 Jun 11;204(6):1405-16. doi: 10.1084/jem.20062363. Epub 2007 May 29. PMID: 17535971; PMCID: PMC2118607.
Comprehensive mapping of immune perturbations associated with severe COVID-19
Kuri-Cervantes L, Pampena MB, Meng W, Rosenfeld AM, Ittner CAG, Weisman AR, Agyekum RS, Mathew D, Baxter AE, Vella LA, Kuthuru O, Apostolidis SA, Bershaw L, Dougherty J, Greenplate AR, Pattekar A, Kim J, Han N, Gouma S, Weirick ME, Arevalo CP, Bolton MJ, Goodwin EC, Anderson EM, Hensley SE, Jones TK, Mangalmurti NS, Luning Prak ET, Wherry EJ, Meyer NJ, Betts MR. Sci Immunol. 2020 Jul 15;5(49):eabd7114. doi: 10.1126/sciimmunol.abd7114. PMID: 32669287; PMCID: PMC7402634.