Our publications
Showing our recent 20 publications from our lab and collaborations with other labs.
Click here to see all our lab's publications on PubMed.
(last updated 2025.10.17)
Click here to see all our lab's publications on PubMed.
(last updated 2025.10.17)
Transient tissue residency and lymphatic egress define human CD56bright NK cell homeostasis
Niehrs A, Hertwig L, Buggert M, Nordström I, Statzu M, Pampena MB, Samer S, Knox JJ, Strunz B, Sun D, Nguyen S, Janoschka C, Xing Y, Wu VH, Sparrelid E, Alisjahbana A, Gao Y, Sleiers N, Strauss O, Filipovic I, Ponzetta A, Medina-Andrade I, Nilsén V, Jorns C, Cornillet M, Maucourant C, Ziegenhain C, Hengst J, Tweet G, Kroll K, Golden GJ, Wedemeyer H, Kürtüncü M, Dori Y, Itkin MG, Klotz L, Schaffer M, Ericzon BG, Ivarsson MA, Paiardini M, Nowak G, Willinger T, Reeves RK, Betts MR, Björkström NK. Nat Immunol. 2025 Oct 14. doi: 10.1038/s41590-025-02290-9. Epub ahead of print. PMID: 41087727.
Therapeutic CD8+ T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound
Pampena MB, Samer S, Viox EG, Nguyen K, Deleage C, Kuri-Cervantes L, Regan J, Wu VH, Docken S, Safrit JT, Bar KJ, Keele BF, Davenport MP, Paiardini M, Betts MR. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2501037122. doi: 10.1073/pnas.2501037122. Epub 2025 Aug 14. PMID: 40811471; PMCID: PMC12377730.
Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Posgai AL, Prak ETL, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. bioRxiv [Preprint]. 2025 May 30:2025.05.19.654940. doi: 10.1101/2025.05.19.654940. PMID: 40475580; PMCID: PMC12139852.
Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Golden GJ, Wu VH, Hamilton JT, Amses KR, Shapiro MR, Sada Japp A, Liu C, Pampena MB, Kuri-Cervantes L, Knox JJ, Gardner JS; HPAP Consortium; Atkinson MA, Brusko TM, Luning Prak ET, Kaestner KH, Naji A, Betts MR. Nat Commun. 2025 May 18;16(1):4621. doi: 10.1038/s41467-025-59626-0. PMID: 40383826; PMCID: PMC12086209.
The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
Tondello C, Bender C, Golden GJ, Puppe D, Blickberndt E, Bayer M, Buchmann GK, Pfeilschifter J, Bachmann M, Hintermann E, Brandes RP, Betts MR, Kroczek RA, Christen U. JCI Insight. 2025 Feb 27;10(7):e178743. doi: 10.1172/jci.insight.178743. PMID: 40014407; PMCID: PMC11981631.
Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease
Naiditch H, Betts MR, Larman HB, Levi M, Rosenberg AZ. Front Immunol. 2025 Feb 12;15:1376654. doi: 10.3389/fimmu.2024.1376654. PMID: 40012912; PMCID: PMC11861071.
No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data
Manduchi E, Descamps HC, Schug J, Da T, Lahori D, El-Mekkoussi H, Betts MR, Kaestner KH. Diabetes. 2024 Oct 1;73(10):1697-1704. doi: 10.2337/db24-0076. PMID: 39083653; PMCID: PMC11417435.
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Strongin Z, Raymond Marchand L, Deleage C, Pampena MB, Cardenas MA, Beusch CM, Hoang TN, Urban EA, Gourves M, Nguyen K, Tharp GK, Lapp S, Rahmberg AR, Harper J, Del Rio Estrada PM, Gonzalez-Navarro M, Torres-Ruiz F, Luna-Villalobos YA, Avila-Rios S, Reyes-Teran G, Sekaly R, Silvestri G, Kulpa DA, Saez-Cirion A, Brenchley JM, Bosinger SE, Gordon DE, Betts MR, Kissick HT, Paiardini M. Nat Immunol. 2024 Jul;25(7):1245-1256. doi: 10.1038/s41590-024-01875-0. Epub 2024 Jun 17. PMID: 38886592; PMCID: PMC11969417.
Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency
Docken SS, McCormick K, Pampena MB, Samer S, Lindemuth E, Pinkevych M, Viox EG, Wu Y, Schlub TE, Cromer D, Keele BF, Paiardini M, Betts MR, Bar KJ, Davenport MP. PLoS Pathog. 2023 Nov 30;19(11):e1011755. doi: 10.1371/journal.ppat.1011755. PMID: 38032851; PMCID: PMC10688670.
Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers
Bordoloi D, Kulkarni AJ, Adeniji OS, Pampena MB, Bhojnagarwala PS, Zhao S, Ionescu C, Perales-Puchalt A, Parzych EM, Zhu X, Ali AR, Cassel J, Zhang R, Betts MR, Abdel-Mohsen M, Weiner DB. Sci Adv. 2023 Nov 3;9(44):eadh4379. doi: 10.1126/sciadv.adh4379. Epub 2023 Nov 1. PMID: 37910620; PMCID: PMC10619929.
Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication
Pinkevych M, Docken SS, Okoye AA, Fennessey CM, Del Prete GQ, Pino M, Harper JL, Betts MR, Paiardini M, Keele BF, Davenport MP. PLoS Pathog. 2023 Oct 6;19(10):e1011660. doi: 10.1371/journal.ppat.1011660. PMID: 37801446; PMCID: PMC10558076.
Human circulating and tissue-resident memory CD8+ T cells
Buggert M, Price DA, Mackay LK, Betts MR. Nat Immunol. 2023 Jul;24(7):1076-1086. doi: 10.1038/s41590-023-01538-6. Epub 2023 Jun 22. Erratum in: Nat Immunol. 2023 Sep;24(9):1591. doi: 10.1038/s41590-023-01586-y. PMID: 37349380.
Lymph-Node-Based CD3+ CD20+ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection
Samer S, Chowdhury A, Wiche Salinas TR, Estrada PMDR, Reuter M, Tharp G, Bosinger S, Cervasi B, Auger J, Gill K, Ablanedo-Terrazas Y, Reyes-Teran G, Estes JD, Betts MR, Silvestri G, Paiardini M. J Virol. 2023 Jun 29;97(6):e0176022. doi: 10.1128/jvi.01760-22. Epub 2023 May 23. PMID: 37223960; PMCID: PMC10308947.
Multivariate indicators of disease severity in COVID-19
Bean J, Kuri-Cervantes L, Pennella M, Betts MR, Meyer NJ, Hassan WM. Sci Rep. 2023 Mar 29;13(1):5145. doi: 10.1038/s41598-023-31683-9. PMID: 36991002; PMCID: PMC10054197.
Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection
Jin W, Fang M, Sayin I, Smith C, Hunter JL, Richardson B, Golden JB, Haley C, Schmader KE, Betts MR, Tyring SK, Cameron CM, Cameron MJ, Canaday DH. Pathog Immun. 2023 Feb 17;7(2):171-188. doi: 10.20411/pai.v7i2.560. PMID: 36865570; PMCID: PMC9973729.
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir
Wu VH, Nordin JML, Nguyen S, Joy J, Mampe F, Del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA, Betts MR. Nat Immunol. 2023 Feb;24(2):359-370. doi: 10.1038/s41590-022-01371-3. Epub 2022 Dec 19. PMID: 36536105; PMCID: PMC9892009.
Validating a Proteomic Signature of Severe COVID-19
Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ. Crit Care Explor. 2022 Dec 1;4(12):e0800. doi: 10.1097/CCE.0000000000000800. PMID: 36479446; PMCID: PMC9722553.
The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Anikeeva N, Steblyanko M, Kuri-Cervantes L, Buggert M, Betts MR, Sykulev Y. Nat Commun. 2022 Oct 28;13(1):6436. doi: 10.1038/s41467-022-34157-0. PMID: 36307445; PMCID: PMC9616955.
Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques
Pino M, Pagliuzza A, Pampena MB, Deleage C, Viox EG, Nguyen K, Shim I, Zhang A, Harper JL, Samer S, King CT, Cervasi B, Gill KP, Ehnert S, Jean SM, Freeman ML, Lifson JD, Kulpa D, Betts MR, Chomont N, Lederman MM, Paiardini M. Nat Commun. 2022 Aug 27;13(1):5055. doi: 10.1038/s41467-022-32698-y. PMID: 36030289; PMCID: PMC9420154.
Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection
Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L; MGH COVID-19 Collection & Processing Team, Meyer NJ, Betts MR, Li JZ, Walker BD, Yu XG, Yonker LM, Luban J. Elife. 2022 Mar 11;11:e74681. doi: 10.7554/eLife.74681. PMID: 35275061; PMCID: PMC9038195.
Niehrs A, Hertwig L, Buggert M, Nordström I, Statzu M, Pampena MB, Samer S, Knox JJ, Strunz B, Sun D, Nguyen S, Janoschka C, Xing Y, Wu VH, Sparrelid E, Alisjahbana A, Gao Y, Sleiers N, Strauss O, Filipovic I, Ponzetta A, Medina-Andrade I, Nilsén V, Jorns C, Cornillet M, Maucourant C, Ziegenhain C, Hengst J, Tweet G, Kroll K, Golden GJ, Wedemeyer H, Kürtüncü M, Dori Y, Itkin MG, Klotz L, Schaffer M, Ericzon BG, Ivarsson MA, Paiardini M, Nowak G, Willinger T, Reeves RK, Betts MR, Björkström NK. Nat Immunol. 2025 Oct 14. doi: 10.1038/s41590-025-02290-9. Epub ahead of print. PMID: 41087727.
Therapeutic CD8+ T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound
Pampena MB, Samer S, Viox EG, Nguyen K, Deleage C, Kuri-Cervantes L, Regan J, Wu VH, Docken S, Safrit JT, Bar KJ, Keele BF, Davenport MP, Paiardini M, Betts MR. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2501037122. doi: 10.1073/pnas.2501037122. Epub 2025 Aug 14. PMID: 40811471; PMCID: PMC12377730.
Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Posgai AL, Prak ETL, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. bioRxiv [Preprint]. 2025 May 30:2025.05.19.654940. doi: 10.1101/2025.05.19.654940. PMID: 40475580; PMCID: PMC12139852.
Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Golden GJ, Wu VH, Hamilton JT, Amses KR, Shapiro MR, Sada Japp A, Liu C, Pampena MB, Kuri-Cervantes L, Knox JJ, Gardner JS; HPAP Consortium; Atkinson MA, Brusko TM, Luning Prak ET, Kaestner KH, Naji A, Betts MR. Nat Commun. 2025 May 18;16(1):4621. doi: 10.1038/s41467-025-59626-0. PMID: 40383826; PMCID: PMC12086209.
The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
Tondello C, Bender C, Golden GJ, Puppe D, Blickberndt E, Bayer M, Buchmann GK, Pfeilschifter J, Bachmann M, Hintermann E, Brandes RP, Betts MR, Kroczek RA, Christen U. JCI Insight. 2025 Feb 27;10(7):e178743. doi: 10.1172/jci.insight.178743. PMID: 40014407; PMCID: PMC11981631.
Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease
Naiditch H, Betts MR, Larman HB, Levi M, Rosenberg AZ. Front Immunol. 2025 Feb 12;15:1376654. doi: 10.3389/fimmu.2024.1376654. PMID: 40012912; PMCID: PMC11861071.
No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data
Manduchi E, Descamps HC, Schug J, Da T, Lahori D, El-Mekkoussi H, Betts MR, Kaestner KH. Diabetes. 2024 Oct 1;73(10):1697-1704. doi: 10.2337/db24-0076. PMID: 39083653; PMCID: PMC11417435.
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Strongin Z, Raymond Marchand L, Deleage C, Pampena MB, Cardenas MA, Beusch CM, Hoang TN, Urban EA, Gourves M, Nguyen K, Tharp GK, Lapp S, Rahmberg AR, Harper J, Del Rio Estrada PM, Gonzalez-Navarro M, Torres-Ruiz F, Luna-Villalobos YA, Avila-Rios S, Reyes-Teran G, Sekaly R, Silvestri G, Kulpa DA, Saez-Cirion A, Brenchley JM, Bosinger SE, Gordon DE, Betts MR, Kissick HT, Paiardini M. Nat Immunol. 2024 Jul;25(7):1245-1256. doi: 10.1038/s41590-024-01875-0. Epub 2024 Jun 17. PMID: 38886592; PMCID: PMC11969417.
Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency
Docken SS, McCormick K, Pampena MB, Samer S, Lindemuth E, Pinkevych M, Viox EG, Wu Y, Schlub TE, Cromer D, Keele BF, Paiardini M, Betts MR, Bar KJ, Davenport MP. PLoS Pathog. 2023 Nov 30;19(11):e1011755. doi: 10.1371/journal.ppat.1011755. PMID: 38032851; PMCID: PMC10688670.
Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers
Bordoloi D, Kulkarni AJ, Adeniji OS, Pampena MB, Bhojnagarwala PS, Zhao S, Ionescu C, Perales-Puchalt A, Parzych EM, Zhu X, Ali AR, Cassel J, Zhang R, Betts MR, Abdel-Mohsen M, Weiner DB. Sci Adv. 2023 Nov 3;9(44):eadh4379. doi: 10.1126/sciadv.adh4379. Epub 2023 Nov 1. PMID: 37910620; PMCID: PMC10619929.
Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication
Pinkevych M, Docken SS, Okoye AA, Fennessey CM, Del Prete GQ, Pino M, Harper JL, Betts MR, Paiardini M, Keele BF, Davenport MP. PLoS Pathog. 2023 Oct 6;19(10):e1011660. doi: 10.1371/journal.ppat.1011660. PMID: 37801446; PMCID: PMC10558076.
Human circulating and tissue-resident memory CD8+ T cells
Buggert M, Price DA, Mackay LK, Betts MR. Nat Immunol. 2023 Jul;24(7):1076-1086. doi: 10.1038/s41590-023-01538-6. Epub 2023 Jun 22. Erratum in: Nat Immunol. 2023 Sep;24(9):1591. doi: 10.1038/s41590-023-01586-y. PMID: 37349380.
Lymph-Node-Based CD3+ CD20+ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection
Samer S, Chowdhury A, Wiche Salinas TR, Estrada PMDR, Reuter M, Tharp G, Bosinger S, Cervasi B, Auger J, Gill K, Ablanedo-Terrazas Y, Reyes-Teran G, Estes JD, Betts MR, Silvestri G, Paiardini M. J Virol. 2023 Jun 29;97(6):e0176022. doi: 10.1128/jvi.01760-22. Epub 2023 May 23. PMID: 37223960; PMCID: PMC10308947.
Multivariate indicators of disease severity in COVID-19
Bean J, Kuri-Cervantes L, Pennella M, Betts MR, Meyer NJ, Hassan WM. Sci Rep. 2023 Mar 29;13(1):5145. doi: 10.1038/s41598-023-31683-9. PMID: 36991002; PMCID: PMC10054197.
Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection
Jin W, Fang M, Sayin I, Smith C, Hunter JL, Richardson B, Golden JB, Haley C, Schmader KE, Betts MR, Tyring SK, Cameron CM, Cameron MJ, Canaday DH. Pathog Immun. 2023 Feb 17;7(2):171-188. doi: 10.20411/pai.v7i2.560. PMID: 36865570; PMCID: PMC9973729.
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir
Wu VH, Nordin JML, Nguyen S, Joy J, Mampe F, Del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA, Betts MR. Nat Immunol. 2023 Feb;24(2):359-370. doi: 10.1038/s41590-022-01371-3. Epub 2022 Dec 19. PMID: 36536105; PMCID: PMC9892009.
Validating a Proteomic Signature of Severe COVID-19
Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ. Crit Care Explor. 2022 Dec 1;4(12):e0800. doi: 10.1097/CCE.0000000000000800. PMID: 36479446; PMCID: PMC9722553.
The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Anikeeva N, Steblyanko M, Kuri-Cervantes L, Buggert M, Betts MR, Sykulev Y. Nat Commun. 2022 Oct 28;13(1):6436. doi: 10.1038/s41467-022-34157-0. PMID: 36307445; PMCID: PMC9616955.
Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques
Pino M, Pagliuzza A, Pampena MB, Deleage C, Viox EG, Nguyen K, Shim I, Zhang A, Harper JL, Samer S, King CT, Cervasi B, Gill KP, Ehnert S, Jean SM, Freeman ML, Lifson JD, Kulpa D, Betts MR, Chomont N, Lederman MM, Paiardini M. Nat Commun. 2022 Aug 27;13(1):5055. doi: 10.1038/s41467-022-32698-y. PMID: 36030289; PMCID: PMC9420154.
Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection
Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L; MGH COVID-19 Collection & Processing Team, Meyer NJ, Betts MR, Li JZ, Walker BD, Yu XG, Yonker LM, Luban J. Elife. 2022 Mar 11;11:e74681. doi: 10.7554/eLife.74681. PMID: 35275061; PMCID: PMC9038195.